Pegylated interferon associated lichen planus at the injection site

Pegylated interferon alpha-2b (PEG-IFN) is a formu- lation of recombinant human interferon conjugated with polyethylene glycol. Compared with standard interferon, pegylated interferon has a longer half-life and superior antiviral efficacy in the treatment of hepatitis C. So it has become the standard therapy with ribavirin for the treat- ment of chronic hepatitis C (CHC) (1). One of the side effects of pegylated interferon is localized inflammatory skin lesions such as eczematous reactions, cutaneous necrosis and vitiligo at the injection site. Herein we report the first case of lichen planus (LP) at the injection site due to pegylated interferon and ribavirin combina- tion therapy.